Causes
- Depletion of monoamine neurotransmitters — serotonin
- norepinephrine and dopamine — chronic neuroinflammation
- trauma
Symptoms
- Anhedonia or inability to feel joy
- profound despair
- severe fatigue
- drastic appetite shifts
- suicidal ideation
Risk Factors
- Severe bereavement or loss
- family history
- chronic disabling illness
- isolation
- substance dependency